Patch-clamp recordings demonstrated that LHON neurons, which typically exhibit impaired sodium and potassium currents, showed restored electrophysiological function after co-culture with MSCs.

Children born to women who carry pathogenic variants in mitochondrial DNA (mtDNA) are at risk for a range of clinical syndromes collectively known as mtDNA disease. Mitochondrial donation by ...

Somatic nuclear mitochondrial DNA (Numt) insertions are mito-nuclear gene transfer events that can arise in the germline and in cancer. This study shows that Numt insertions arise spontaneously and ...

Despite being renowned as the “powerhouse of the cell,” mitochondria can also be a source of heartache for those living with mitochondrial disease—especially when planning to have children. Because ...

One study reported 8 live births from 22 women with pathogenic mtDNA variants who underwent mitochondrial donation through pronuclear transfer. None had signs of mitochondrial disease and heteroplasmy ...

A technique to allow women who carry diseases in their mitochondrial DNA to have healthy children has been performed successfully eight times since being legalized, two papers have announced. With one ...

Women who carry pathogenic variants in their mitochondrial DNA (mtDNA) can pass these onto their children, causing incurable mitochondrial diseases that are progressive and debilitating. For women who ...