Adhesion GPCRs are a large class of surface proteins that recognize chemical and mechanical stimuli in the body. The rapidly expanding body of knowledge on the therapeutic targeting of these receptors ...

Scientists have unlocked new details on important receptor proteins—promising targets for the creation of novel drugs for metabolic conditions ranging from diabetes to obesity and inflammatory ...

A protein that is a key modulator of fat, glucose and cholesterol levels in the body usually works in tandem with another ...

Researchers used GPS-like tracking to observe how a key G protein-coupled receptor (GPCR) moves, revealing the core mechanism behind vital body functions. G protein-coupled receptors are embedded in ...

G protein-coupled receptors (GPCRs) are expressed on the surface of cells and regulate a range of important functions. Because they are involved in so many sensory and physiological processes, ...

Hitting targets embedded within the cell membrane has long been difficult for drug developers due to the membrane's challenging biochemical properties. Now, chemists have demonstrated new ...

Researchers have uncovered how a protein called MRAP2 acts as a key regulator of hunger. It helps move the appetite receptor MC4R to the cell’s surface, allowing it to send stronger “stop eating” ...

Scientists from the Riken Center for Sustainable Resource Science (CSRS) in Japan have identified an ancient protein that, with modifications, could confer broad-spectrum protection for plants against ...

For the first time, researchers have determined how a human olfactory receptor captures an airborne scent molecule, the pivotal chemical event that triggers our sense of smell. Whether it evokes roses ...